CYP2C9 polymorphism and warfarin dose requirements
نویسندگان
چکیده
منابع مشابه
Polymorphism Detection of VKORC1 and CYP2C9 Genes for Warfarin Dose Adjustment by Real-Time PCR
1Food and Drug Laboratory Research Center, Ministry of Health and Medical Education, Tehran, IR Iran 2Day General Hospital Laboratory, Tehran, IR Iran 3Department of Biotechnology, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran 4Department of Research and Development, Production and Research Complex, Pasteur Institute, Tehran, IR Iran 5Department of Epidemiology, Pasteur Instit...
متن کاملEffect of CYP2C9 and VKORC1 genetic variations on warfarin dose requirements in Indian patients.
BACKGROUND Warfarin, an oral anticoagulant is used in patients who are at increased risk of developing blood clots. The management of warfarin therapy is challenging because it shows large inter and intra individual variability in patient response due to factors like age, gender, diet, concurrent drug interactions and variations in CYP2C9 and VKORC1 genes. Studies implicate that polymorphisms i...
متن کاملThe effect of CYP2C9 and VKORC1 genetic polymorphisms on warfarin dose requirements in a pediatric population
OBJECTIVE The aim was to investigate the frequency of genetic polymorphisms of cytochrome P4502C9 (CYP2C9) and vitamin K epoxide reductase complex subunit1 (VKORC1) and determine the effect of these polymorphisms on warfarin dose requirements in pediatric patients. METHODS Fifty-eight pediatric patients with cardiac disease, thrombophilia, or other conditions, taking a stable warfarin dose, a...
متن کاملpolymorphism detection of vkorc1 and cyp2c9 genes for warfarin dose adjustment by real-time pcr
conclusions simpleprobe® real-time pcr is a fast and accurate technique qualified to detect vkorc1 and cyp2c9 snps. these results encourage taking further steps towards using vkorc1 and cyp2c9 allelic screening to prevent clinical complications due to resistance or sensitivity to warfarin as well as anti-coagulant dose adjustment. results the allelic frequencies for vkorc1 c1173t (cc, ct, tt) w...
متن کاملVKORC1 and CYP2C9 genotypic data-based dose prediction alone does not accurately predict warfarin dose requirements in some Malaysian patients.
BACKGROUND/AIM VKORC1 and CYP2C9 genetic polymorphisms may not accurately predict warfarin dose requirements. We evaluated an existing warfarin dosing algorithm developed for Malaysian patients that was based only on VKORC1 and CYP2C9 genes. MATERIALS AND METHODS Five Malay patients receiving warfarin maintenance therapy were investigated for their CYP2C9*2, CYP2C9*3, and VKORC1-1639G>A genot...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2002
ISSN: 0306-5251
DOI: 10.1046/j.1365-2125.2002.01572_6.x